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KMID : 0352519920290010393
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Korea Univercity Medical Journal
1992 Volume.29 No. 1 p.393 ~ p.404
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Feline Cortical SEPs during Fentanyl, Nalbuphine, or Enflurane Anesthesia followed by Spinal Cord Injury and Naloxone
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Abstract
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Spinal cord injury may occur during surgical correction of spinal deformicy, In this situations. opiate receptor agonists have known to aggravate spinal cord damage whereas, opiate receptor antagonists(naloxone) have demonstrated to protect it.
Because
opioids or inhalational anesthetics are used clinically, the effect of an opiate antagonist was evaluated by cortical somatosensory evoked potentials (cortical SEPs) which occur in 28 cats undergoing compressive injury on the posterior spinal
cord
during fentanyl, nalbuphine, and enflurane anesthesia.
Anesthesia was induced with pentobarbiturate (50mg/k, im). a balloon tipped catheter was inserted in the epidural space with the tip located at thoracolumbar junction. Spinal cord compressive injury was produced by balloon inflation during
intravenous
saline infusion(control group) and fentanyl group 1). nalbuphine(group 2) and enflurane(group 3) anesthesia. Naloxone(2mg/Kg) was administered intravenously following injury to all animals. Cortical SEPs were determined before and after induction
of
anesthesia, during the compressive injury for 5 minutes, 10 minutes. 15 minutes 29 minutes. after naloxone infusion, and after removal of compressive injury.
General anesthesia ???sulted in increases of latency and reductions of amplitude in the cortical SEPs. The reduction of amplitude were more marked than increases of latency in group 1,2 and 3. During the ???l injury group 2 and 3 resulted in less
alterations of latencies than group 1. But there were no significant differences among the groups. The administration of naloxone far improved latencies and amplitudes of group 1 more than other two groups. but there were no significant
differences
among the groups. Less recovery of the cortical SEPs response to naloxone in control group than the other groups.
These results do not support the supposition that opioid anesthesia produces an adverse effect upon cortical SEPs following spinal cord compressive injury.
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